Laurea Magistrale in Medicina e Chirurgia - sede di Torino

• The membrane • Protein compartmentalization • Mitochondria and ATP synthesis • Receptors • Cytoskeleton • Cellular interactions in tissue development and homeostasis • Cell cycle and mitosis

General and Molecular Genetics Mechanisms of Genetic Inheritance

• DNA replication • Organization and dynamics of the eukaryotic genome • RNA transcription • Protein synthesis • Mutations • Gene expression control • Basics of bacterial genetics • Mendelian analysis

Molecular Biology

From the formal concept to the molecular concept of genes: isolation and cloning of genes. Recombinant DNA technology Gene and genome sequencing The human genome and other genomes Approaches for individual genotype analysis Epigenetic mechanisms of gene expression control in differentiation and development Post-transcriptional gene expression control Non-coding RNA Approaches for measuring gene expression Gene expression manipulation in different organisms Strategies for gene expression manipulation in human cells for therapeutic purposes Human genetics

Human genetics

• The role of genetics in medicine
• The concept of genetic variants. Classification of variants and the main genetic tests used to study them
• Disease-causing variants in monogenic disorders. The main inheritance patterns of monogenic diseases with numerous examples
• Genetics of complex traits and complex diseases (with various examples)
• Introduction to cancer genetics
• Introduction to population genetics
• Introduction to immunogenetics (histocompatibility genetics) and its role in transplant medicine

Note: The link to the Moodle page for the modules of Cellular Biology and General and Molecular Genetics (SSD BIO/13) (SME0881) is: 

https://elearning.unito.it/medicina/course/view.php?id=12134#section-1 where you can find all the educational materials.

For the section on BIOLOGICAL BASES:

• Miriam Martini: Molecular Genetics
• Alessandra Ghigo: Cell Biology
• Paolo Porporato: Formal Genetics

For the section on MOLECULAR BIOLOGY:

• Daniela Taverna (general BIOMOLECULAR part)
• Raffaele Calogero (specific BIOMOLECULAR part for SEQUENCING)

For the Human Genetics section, all teaching materials can be found on Moodle (path: Corsi > LAUREE MAGISTRALI A CICLO UNICO > A.A. in corso > LAUREA MAGISTRALE A CICLO UNICO IN MEDICINA E CHIRURGIA – TORINO > PRIMO ANNO > GENETICA UMANA_BASI BIOLOGICHE, MOLECOLARI E DI GENETICA UMANA_TORINO (SME0881C)).

Written exam for Cell Biology (2 open-ended questions), Molecular Biology (2 open-ended questions), General Genetics (11 multiple-choice/semi-open questions).

Written exam for Molecular Biology: 4 open-ended questions (TAVERNA) and 5 multiple-choice questions (CALOGERO). There is the possibility to request an oral exam, if the written exam score is sufficient, to improve the grade. During the course, every student will be REQUIRED to complete exercises and answer questions to be submitted on the Moodle site by a specified deadline (towards the end of the course). Completing this assignment can earn up to 4 additional points, which will be added to the exam score. Without submitting on Moodle, you CANNOT access the exam. The maximum final score, "ASSIGNMENTS + EXAM," is 34 points.

Written exam for Human Genetics:a 40-minute written exam consisting of 31 multiple-choice questions (4-5 possible answers, with only one correct answer; 1 point for each correct answer, 0 points for each incorrect or unanswered question).

The exam will focus on the topics presented during lectures and according to the instructions provided by the professors."

No support activities are provided for Biological Bases.

For Human Genetics, bibliographic references related to the topics covered will be provided.

For Molecular Biology, towards the end of the course, a tutor will be available for those interested, for a total of 4-6 hours, to review the "assignments."