Paolo Michieli
Ricercatore/Ricercatrice universitario/a
- Centro Interdipartimentale di Ricerca per le Biotecnologie Molecolari - MBC
- SSD: BIO/17 - istologia
- ORCID: orcid.org/0000-0002-3093-8871
Contatti
- +39 011 6706439
- paolo.michieli@unito.it
- Molecular Biotechnology Center
Via Nizza 52, 10126 Torino (TO), Italy - https://medchirurgia.campusnet.unito.it/do/docenti.pl/Show?_id=pmichiel
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Presso
- Department of Oncology
- Dipartimento di Oncologia
- Laurea Magistrale in Medicina e Chirurgia - sede di Torino
Curriculum vitae
Prodotti della ricerca selezionati
Microscope-Based Automated Quantification of Liver Fibrosis in Mice Using a Deep Learning Algorithm
2021-01-01 Ramot, Yuval; Deshpande, Ameya; Morello, Virginia; Michieli, Paolo; Shlomov, Tehila; Nyska, Abraham https://iris.unito.it/handle/2318/1894263
A Mesenchymal-epithelial transition factor-Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy
2021-01-01 Ma K.; Que W.; Hu X.; Guo W.-Z.; Gu E.-L.; Zhong L.; Morello V.; Cazzanti M.; Michieli P.; Takahara T.; Li X.-K. https://iris.unito.it/handle/2318/1847979
The nhance® mutation-equipped anti-met antibody argx-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients
2021-01-01 Aftimos P.; Rolfo C.; Rottey S.; Barthelemy P.; Borg C.; Park K.; Oh D.-Y.; Kim S.-W.; De Jonge N.; Hanssens V.; Zwanenpoel K.; Molthoff C.; Vugts D.; Dreier T.; Verheesen P.; van Dongen G.A.M.S.; Jacobs J.; Van Rompaey L.; Hultberg A.; Michieli P.; Pauwels P.; Fung S.; Thibault A.; de Haard H.; Leupin N.; Awada A. https://iris.unito.it/handle/2318/1847990
Correction: Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis
2019-01-01 Cassano, Marco; Biressi, Stefano; Finan, Amanda; Benedetti, Laura; Omes, Claudia; Boratto, Renata; Martin, Frank; Allegretti, Marcello; Broccoli, Vania; Cusella De Angelis, Gabriella; Comoglio, Paolo M; Basilico, Cristina; Torrente, Yvan; Michieli, Paolo; Cossu, Giulio; Sampaolesi, Maurilio https://iris.unito.it/handle/2318/1894264
Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
2017-01-01 Mira, Alessia; Morello, Virginia; Céspedes, Maria Virtudes; Perera, Timothy; Comoglio, Paolo M.; Mangues, Ramon; Michieli, Paolo https://iris.unito.it/handle/2318/1671373
Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody
2016-01-01 Cignetto, Simona; Modica, Chiara; Chiriaco, Cristina; Fontani, Lara; Milla, Paola; Michieli, Paolo; Comoglio, Paolo M.; Vigna, Elisa https://iris.unito.it/handle/2318/1633002
Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy
2016-01-01 Godar, Marie; Morello, Virginia; Sadi, Ava; Hultberg, Anna; De Jonge, Natalie; Basilico, Cristina; Hanssens, Valérie; Saunders, Michael; Lambrecht, Bart N.; El Khattabi, Mohamed; De Haard, Hans; Michieli, Paolo; Blanchetot, Christophe* https://iris.unito.it/handle/2318/1671374
Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling
2015-01-01 Hultberg, Anna; Morello, Virginia; Huyghe, Leander; De Jonge, Natalie*; Blanchetot, Christophe; Hanssens, Valérie; De Boeck, Gitte; Silence, Karen; Festjens, Els; Heukers, Raimond; Roux, Benjamin; Lamballe, Fabienne; Ginestier, Christophe; Charafe-Jauffret, Emmanuelle; Maina, Flavio; Brouckaert, Peter; Saunders, Michael; Thibault, Alain; Dreier, Torsten; De Haard, Hans; Michieli, Paolo https://iris.unito.it/handle/2318/1671375
ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
2014-01-01 Van Schaeybroeck S;Kalimutho M;Dunne PD;Carson R;Allen W;Jithesh PV;Redmond KL;Sasazuki T;Shirasawa S;Blayney J;Michieli P;Fenning C;Lenz HJ;Lawler M;Longley DB;Johnston PG https://iris.unito.it/handle/2318/149415
Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs.
2014-01-01 Pennacchietti S;Cazzanti M;Bertotti A;Rideout WM ;Han M;Gyuris J;Perera T;Comoglio PM;Trusolino L;Michieli P https://iris.unito.it/handle/2318/149419
Four individually druggable MET hotspots mediate HGF-driven tumor progression.
2014-01-01 Basilico C;Hultberg A;Blanchetot C;de Jonge N;Festjens E;Hanssens V;Osepa SI;De Boeck G;Mira A;Cazzanti M;Morello V;Dreier T;Saunders M;de Haard H;Michieli P https://iris.unito.it/handle/2318/149416
Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor.
2014-01-01 Vigna E;Pacchiana G;Chiriaco C;Cignetto S;Fontani L;Michieli P;Comoglio PM https://iris.unito.it/handle/2318/149414
Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET--response.
2013-01-01 Michieli P;Basilico C;Pennacchietti S https://iris.unito.it/handle/2318/149417
Tivantinib (ARQ197) Displays Cytotoxic Activity That Is Independent of Its Ability to Bind MET
2013-01-01 C. Basilico;S. Pennacchietti;E. Vigna;C. Chiriaco;S. Arena;A. Bardelli;D. Valdembri;G. Serini;P. Michieli https://iris.unito.it/handle/2318/142883
Targeted therapies: Tivantinib-a cytotoxic drug in MET inhibitor's clothes?
2013-01-01 Michieli P; Di Nicolantonio F https://iris.unito.it/handle/2318/136454
Targeted anticancer therapy by a recombinant monovalent antibody against the MET oncogene
2011-01-01 P. Comoglio; E. Vigna; P. Michieli https://iris.unito.it/handle/2318/153663
2011-01-01 T. Takahara; K. Kawai; T. Sugiyama; M. Asahi; P. Michieli
Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody
2010-01-01 G. Pacchiana;C. Chiriaco;M. C. Stella;F. Petronzelli;R. D. Santis;M. Galluzzo;P. Carminati;P. M. Comoglio;P. Michieli;E. Vigna https://iris.unito.it/handle/2318/80859
Expression and Functional Regulation of Myoglobin in Epithelial Cancers
2009-01-01 Flonta SE; Arena S; Pisacane A; Michieli P; Bardelli A https://iris.unito.it/handle/2318/131981
Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe?
2009-01-01 Michieli P https://iris.unito.it/handle/2318/149418
Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis
2009-01-01 Galluzzo M; Pennacchietti S; Rosano S; Comoglio PM; Michieli P https://iris.unito.it/handle/2318/73713
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis
2008-01-01 Takahara T; Xue F; Mazzone M; Yata Y; Nonome K; Kanayama M; Kawai K; Pisacane AM; Takahara S; Li XK; Comoglio PM; Sugiyama T; Michieli P https://iris.unito.it/handle/2318/47763
Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis
2008-01-01 Cassano M; Biressi S; Finan A; Benedetti L; Omes C; Boratto R; Martin F; Allegretti M; Broccoli V; Cusella De Angelis G; Comoglio PM; Basilico C; Torrente Y; Michieli P; Cossu G; Sampaolesi M https://iris.unito.it/handle/2318/29819
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
2008-01-01 Basilico C; Arnesano A; Galluzzo M; Comoglio PM; Michieli P https://iris.unito.it/handle/2318/49806
HGF-MSP chimera protects kidneys from ischemia-reperfusion injury.
2007-01-01 Xue F; Isaka Y; Takahara T; Imamura R; Suzuki C; Ichimaru N; Michieli P; https://iris.unito.it/handle/2318/126246
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
2004-01-01 MICHIELI P; MAZZONE M; BASILICO C; CAVASSA S; SOTTILE A; NALDINI L; P. COMOGLIO https://iris.unito.it/handle/2318/37454
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
2004-01-01 MAZZONE M; BASILICO C; CAVASSA S; PENNACCHIETTI S; RISIO M; NALDINI L; PM COMOGLIO; MICHIELI P https://iris.unito.it/handle/2318/37910
Mutations in the met oncogene unveil a 'dual switch' mechanism controlling tyrosine kinase activity.
2003-01-01 F. CHIARA; P. MICHIELI; L. PUGLIESE; PM. COMOGLIO https://iris.unito.it/handle/2318/38097
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
2003-01-01 S. PENNACCHIETTI; P. MICHIELI; M. GALLUZZO; M. MAZZONE; S. GIORDANO; P. COMOGLIO https://iris.unito.it/handle/2318/39201
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity.
2002-01-01 MICHIELI P; CAVASSA S; BASILICO C; DE LUCA A; MAZZONE M; ASTI C; CHIUSAROLI R; GUGLIELMI M; BOSSU' P; COLOTTA F; CASELLI G; PM COMOGLIO https://iris.unito.it/handle/2318/40004
Different point mutations in the met oncogene elicit distinct biological properties.
2000-01-01 GIORDANO S; MAFFÈ A; WILLIAMS T A; ARTIGIANI S; GUAL P; BARDELLI A; BASILICO C; MICHIELI P; P. COMOGLIO https://iris.unito.it/handle/2318/40054
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists.
1999-01-01 P. MICHIELI; C. BASILICO; S. PENNACCHIETTI; A. MAFFE'; L. TAMAGNONE; S. GIORDANO; A. BARDELLI; P.M. COMOGLIO https://iris.unito.it/handle/2318/36446
MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential.
1999-01-01 WILLIAMS TA; LONGATI P; PUGLIESE L; GUAL P; A. BARDELLI; MICHIELI P https://iris.unito.it/handle/2318/38597
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
1998-01-01 BARDELLI A.; LONGATI P.; GRAMAGLIA D.; BASILICO C.; TAMAGNONE L.; GIORDANO S; BALLINARI D.; MICHIELI P.; P. COMOGLIO https://iris.unito.it/handle/2318/1673
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.
1998-01-01 BOCCACCIO C ;ANDÒ M ;TAMAGNONE L ;BARDELLI A ;MICHIELI P ;BATTISTINI C ;COMOGLIO PM https://iris.unito.it/handle/2318/40234
p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
1996-01-01 Cereseto A;Diella F;Mulloy JC;Cara A;Michieli P;Grassmann R;Franchini G;Klotman ME https://iris.unito.it/handle/2318/149422
Inhibition of oncogene-mediated transformation by ectopic expression of p21Waf1 in NIH3T3 cells.
1996-01-01 Michieli P;Li W;Lorenzi MV;Miki T;Zakut R;Givol D;Pierce JH https://iris.unito.it/handle/2318/149421
Expression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells.
1996-01-01 Li W;Michieli P;Alimandi M;Lorenzi MV;Wu Y;Wang LH;Heidaran MA;Pierce JH https://iris.unito.it/handle/2318/149420
The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction.
1995-01-01 Wang LM;Michieli P;Lie WR;Liu F;Lee CC;Minty A;Sun XJ;Levine A;White MF;Pierce JH https://iris.unito.it/handle/2318/149423
Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).
1994-01-01 Huppi K;Siwarski D;Dosik J;Michieli P;Chedid M;Reed S;Mock B;Givol D;Mushinski JF https://iris.unito.it/handle/2318/149426
Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta.
1994-01-01 Li W;Yu JC;Michieli P;Beeler JF;Ellmore N;Heidaran MA;Pierce JH https://iris.unito.it/handle/2318/149428
A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.
1994-01-01 Chedid M;Michieli P;Lengel C;Huppi K;Givol D https://iris.unito.it/handle/2318/149425
A novel dual specificity phosphatase induced by serum stimulation and heat shock.
1994-01-01 Ishibashi T;Bottaro DP;Michieli P;Kelley CA;Aaronson SA https://iris.unito.it/handle/2318/149424
Induction of WAF1/CIP1 by a p53-independent pathway.
1994-01-01 Michieli P;Chedid M;Lin D;Pierce JH;Mercer WE;Givol D https://iris.unito.it/handle/2318/149427
Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.
1993-01-01 Donghi R;Longoni A;Pilotti S;Michieli P;Della Porta G;Pierotti MA https://iris.unito.it/handle/2318/149429
TaqI RFLP of the human tropomyosin gene (TPM3) involved in the generation of the TRK oncogene.
1991-01-01 Michieli P;Pierotti MA;De Benedetti V;Donghi R;Mondini P;Radice P;Della Porta G https://iris.unito.it/handle/2318/149430
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