Carla Boccaccio
Professore/Professoressa associato/a
- Dipartimento di Oncologia
- SSD: BIO/17 - istologia

Contatti
- 0119933238
- 0119933225
- carla.boccaccio@unito.it
- Laboratory of Cancer Stem Cell Research
Candiolo Cancer Institute, FPO-IRCCS
10060 Candiolo, Torino - https://medchirurgia.campusnet.unito.it/persone/carla.boccaccio
- VCard contatti
- QRcode contatti
Presso
- Department of Oncology
- Dipartimento di Oncologia
- Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
- Laurea Magistrale in Medicina e Chirurgia - sede di Torino
- Programma MD-PhD della Scuola di Medicina
- Dottorato in Medicina Molecolare
Pubblicazioni selezionate
Verginelli F , Pisacane A , Gambardella G , D', Ambrosio A , Candiello E , Ferrio M , Panero M , Casorzo L , Benvenuti S , Cascardi E , Senetta R , Geuna E , Ballabio A , Montemurro F , Sapino A , Comoglio P M , Boccaccio C (2021)
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition.
https://iris.unito.it/handle/2318/1795380
De Bacco, Francesca, Orzan, Francesca, Erriquez, Jessica, Casanova, Elena, Barault, Ludovic, Albano, Raffaella, D’Ambrosio, Antonio, Bigatto, Viola, Reato, Gigliola, Patanè, Monica, Pollo, Bianca, Kuesters, Geoffrey, Dell’Aglio, Carmine, Casorzo, Laura, Pellegatta, Serena, Finocchiaro, Gaetano, Comoglio, Paolo M , Boccaccio, Carla (2021)
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
https://iris.unito.it/handle/2318/1795377
De Bacco F , Boccaccio C (2021)
ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference.
https://iris.unito.it/handle/2318/1858353
Benvenuti S , Milan M , Geuna E , Pisacane A , Senetta R , Gambardella G , Stella G M , Montemurro F , Sapino A , Boccaccio C , Comoglio P M (2020)
Cancer of Unknown Primary (CUP): genetic evidence for a novel nosological entity? A case report.
https://iris.unito.it/handle/2318/1762339
Simonelli M , Dipasquale A , Orzan F , Lorenzi E , Persico P , Navarria P , Pessina F , Nibali M C , Bello L , Santoro A , Boccaccio C (2020)
Cerebrospinal fluid tumor DNA for liquid biopsy in glioma patients’ management: Close to the clinic?
https://iris.unito.it/handle/2318/1778349
Gallo S , Spilinga M , Albano R , Ferrauto G , Di Gregorio E , Casanova E , Balmativola D , Bonzano A , Boccaccio C , Sapino A , Comoglio P M , Crepaldi T (2020)
Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro.
https://iris.unito.it/handle/2318/1742849
Lupo, Barbara, Sassi, Francesco, Pinnelli, Marika, Galimi, Francesco, Zanella, Eugenia R , Vurchio, Valentina, Migliardi, Giorgia, Gagliardi, Paolo Armando, Puliafito, Alberto, Manganaro, Daria, Luraghi, Paolo, Kragh, Michael, Pedersen, Mikkel W , Horak, Ivan D , Boccaccio, Carla, Medico, Enzo, Primo, Luca, Nichol, Daniel, Spiteri, Inmaculada, Heide, Timon, Vatsiou, Alexandra, Graham, Trevor A , Élez, Elena, Argiles, Guillem, Nuciforo, Paolo, Sottoriva, Andrea, Dienstmann, Rodrigo, Pasini, Diego, Grassi, Elena, Isella, Claudio, Bertotti, Andrea, Trusolino, Livio (2020)
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype.
https://iris.unito.it/handle/2318/1750197
Gallo S , Spilinga M , Casanova E , Bonzano A , Boccaccio C , Comoglio P M , Crepaldi T (2020)
The long-lasting protective effect of HGF in cardiomyoblasts exposed to doxorubicin requires a positive feed-forward loop mediated by ERK1,2-TIMP1-STAT3.
https://iris.unito.it/handle/2318/1770093
Kolling S , Ventre F , Geuna E , Milan M , Pisacane A , Boccaccio C , Sapino A , Montemurro F (2020)
“Metastatic Cancer of Unknown Primary” or “Primary Metastatic Cancer”?
https://iris.unito.it/handle/2318/1768115
Orzan F , Pagani F , Cominelli M , Triggiani L , Calza S , De Bacco F , Medicina D , Balzarini P , Panciani P P , Liserre R , Buglione M , Fontanella M M , Medico E , Galli R , Isella C , Boccaccio C , Poliani P L (2020)
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes.
https://iris.unito.it/handle/2318/1766963
Comoglio, Paolo M *, Trusolino, Livio, Boccaccio, Carla (2018)
Known and novel roles of the MET oncogene in cancer: A coherent approach to targeted therapy.
https://iris.unito.it/handle/2318/1670498
Varese Erica, Peira Giovanni (2018)
Proposta di un modello di sito web per la valorizzazione e la comunicazione delle carni fresche bovine ad indicazione geografica.
https://iris.unito.it/handle/2318/1660924
Luraghi, Paolo, Bigatto, Viola, Cipriano, Elia, Reato, Gigliola, Orzan, Francesca, Sassi, Francesco, De Bacco, Francesca, Isella, Claudio, Bellomo, Sara Erika, Medico, Enzo, Comoglio, Paolo M, Bertotti, Andrea, Trusolino, Livio, Boccaccio, Carla (2018)
A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and non-genetic mechanisms of resistance to anti-EGFR therapy.
https://iris.unito.it/handle/2318/1662775
Isella, Claudio, Brundu, Francesco, Bellomo, Sara E , Galimi, Francesco, Zanella, Eugenia, Porporato, Roberta, Petti, Consalvo, Fiori, Alessandro, Orzan, Francesca, Senetta, Rebecca, Boccaccio, Carla, Ficarra, Elisa, Marchionni, Luigi, Trusolino, Livio, Medico, Enzo, Bertotti, Andrea (2017)
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.
https://iris.unito.it/handle/2318/1642129
Orzan, FRANCESCA NOEMI, DE BACCO, Francesca, Crisafulli, Giovanni, Pellegatta, Serena, Mussolin, Benedetta, Siravegna, Giulia, D', Ambrosio, Antonio, Comoglio, Paolo, Finocchiaro, Gaetano, Boccaccio, Carla (2017)
Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor.
https://iris.unito.it/handle/2318/1651534
De Bacco, Francesca, D', Ambrosio, Antonio, Casanova, Elena, Orzan, Francesca, Neggia, Roberta, Albano, Raffaella, Verginelli, Federica, Cominelli, Manuela, Poliani, Pietro L, Luraghi, Paolo, Reato, Gigliola, Pellegatta, Serena, Finocchiaro, Gaetano, Perera, Timothy, Garibaldi, Elisabetta, Gabriele, Pietro, Comoglio, Paolo M, Boccaccio, Carla (2016)
MET inhibition overcomes radiation resistance of glioblastoma stem-like cells.
https://iris.unito.it/handle/2318/1566856
Kampf, A R , Cámara, F , Ciriotti, M E , Nash, B P , Balestra, C , Chiappino, C (2016)
Castellaroite, Mn2+3(AsO4)2·4.5H2O, a new mineral from Italy related to metaswitzerite.
https://iris.unito.it/handle/2318/1564837
Bigatto, V, De Bacco, F, Casanova, E, Reato, G, Lanzetti, L, Isella, C, Sarotto, I, Comoglio, Pm, Boccaccio, C (2015)
TNF-α promotes invasive growth through the MET signaling pathway.
https://iris.unito.it/handle/2318/1506654
V Bigatto, P Luraghi, E Cipriano, G _Reato, F N Orzan, R Neggia, A Bertotti, L Trusolino, P M Comoglio, C Boccaccio (2015)
Derivation and charaterization of cancer initialling cells representative of metastatic colorectal cancer genetic heterogeneity.
https://iris.unito.it/handle/2318/1708779
Silvia Giordano, Carla Boccaccio, Paolo M Comoglio (2015)
Growth Factor Receptors.
https://iris.unito.it/handle/2318/1523779
Bresciani, S , Giacosa, E , Broccardo, L , Truant, E (2015)
Innovation in family firms: an Italian survey.
https://iris.unito.it/handle/2318/1526989
TRUANT E , BROCCARDO L , CULASSO F (2015)
Adoption and benefits of management accounting practices in Italian SMEs: an explorative survey.
https://iris.unito.it/handle/2318/1526934
Boccaccio C, Luraghi P, Comoglio PM (2014)
MET-Mediated Resistance to EGFR Inhibitors: An Old Liaison Rooted in Colorectal Cancer Stem Cells.
https://iris.unito.it/handle/2318/150408
Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, Bigatto V, De Bacco F, Menietti E, Han M, Rideout WM, Perera T, Bertotti A, Trusolino L, Comoglio PM, Boccaccio C (2014)
MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.
https://iris.unito.it/handle/2318/143265
Boccaccio C, Comoglio PM (2014)
MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure.
https://iris.unito.it/handle/2318/156303
Boccaccio C, Comoglio PM (2013)
The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target.
https://iris.unito.it/handle/2318/127741
S Gastaldi, F Sassi, P Accornero, D Torti, F Galimi, G Migliardi, G Molyneux, T Perera, P M Comoglio, C Boccaccio, M J Smalley, A Bertotti*, L Trusolino* (*Co-Senior Authors) (2013)
Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.
https://iris.unito.it/handle/2318/102410
Luraghi P, Schelter F, Krüger A, Boccaccio C (2012)
The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth.
https://iris.unito.it/handle/2318/131685
S Giordano, C Boccaccio, P M Comoglio (2012)
I recettori per i fattori di crescita.
https://iris.unito.it/handle/2318/107390
De Bacco F, Casanova E, Medico E, Pellegatta S, Orzan F, Albano R, Luraghi P, Reato G, D', Ambrosio A, Porrati P, Patane M, Maderna E, Pollo B, Comoglio PM, Finocchiaro G, Boccaccio C (2012)
The MET oncogene is a functional marker of a glioblastoma stem cell subtype.
https://iris.unito.it/handle/2318/127216
C Boccaccio (2011)
Hepatocyte Growth Factor: A marker and a player in disseminated intravascular coagulation.
https://iris.unito.it/handle/2318/77408
De Bacco F, Luraghi P, Medico E, Reato G, Girolami F, Perera T, Gabriele P, Comoglio PM, Boccaccio C (2011)
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer.
https://iris.unito.it/handle/2318/84086
Schelter F, Grandl M, Seubert B, Schaten S, Hauser S, Gerg M, Boccaccio C, Comoglio P, Krüger A (2011)
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.
https://iris.unito.it/handle/2318/113167
Hwang CI, Matoso A, Corney DC, Flesken-Nikitin A, Körner S, Wang W, Boccaccio C, Thorgeirsson SS, Comoglio PM, Hermeking H, Nikitin AY (2011)
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
https://iris.unito.it/handle/2318/107502
V Bigatto, F De Bacco, Paolo M Comoglio, C Boccaccio (2010)
Exploring the interplay between MET and Tumor Necrosis Factor alpha.
https://iris.unito.it/handle/2318/87754
Schelter F, Kobuch J, Moss ML, Becherer JD, Comoglio PM, Boccaccio C, Krüger A (2010)
A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor.
https://iris.unito.it/handle/2318/99073
C Boccaccio (2010)
L'oncogene MET e la cescita invasiva delle cellule staminali del cancro.
https://iris.unito.it/handle/2318/86820
FINKBEINER MR, ASTANEHE A, TO K, FOTOVATI A, DAVIES AH, ZHAO Y, JIANG H, STRATFORD AL, SHADEO A, BOCCACCIO C, COMOGLIO P, MERTENS PR, EIREW P, RAOUF A, EAVES CJ, DUNN SE (2009)
Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells.
https://iris.unito.it/handle/2318/99922
Boccaccio C, Comoglio P M (2009)
Genetic link between cancer and thrombosis.
https://iris.unito.it/handle/2318/71549
F De Bacco, E Medico, G Reato, P Luraghi, P, Gabriele, P M Comoglio, C Boccaccio (2008)
Ionizing radiation fosters cancer invasion through transcriptional up-regulation of the MET oncogene.
https://iris.unito.it/handle/2318/85725
KANKURI E, BABUSIKOVA O, HLUBINOVA K, SALMENPERA P, BOCCACCIO C, LUBITZ W, HARYULA A, BIZIK J (2008)
Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells.
https://iris.unito.it/handle/2318/107659
C Boccaccio (2007)
The MET oncogene drives a genetic programme for stem and cancer cells.
https://iris.unito.it/handle/2318/87063
C BOCCACCIO, P M COMOGLIO (2007)
Oncogenes, cancer, and haemostasis.
https://iris.unito.it/handle/2318/28520
C Boccaccio (2007)
Colorectal cancer stem cells, MET and metastasis.
https://iris.unito.it/handle/2318/86819
P COMOGLIO, L TRUSOLINO, C BOCCACCIO (2007)
Scatter factor-dependent branching morphogenesis: structural and histological features.
https://iris.unito.it/handle/2318/35354
P M COMOGLIO, C BOCCACCIO (2006)
Scatter factors in tumor progression.
https://iris.unito.it/handle/2318/10936
BOCCACCIO C, COMOGLIO PM (2006)
Invasive growth: a MET-driven genetic programme for cancer and stem cells.
https://iris.unito.it/handle/2318/40108
BOCCACCIO C , MEDICO E (2006)
Cancer and blood coagulation.
https://iris.unito.it/handle/2318/113496
C Boccaccio (2006)
L'oncogene MET regola programmi cellulari che legano il cancro all'emostasi.
https://iris.unito.it/handle/2318/86756
BOCCACCIO C , SABATINO G, MEDICO E , GIROLAMI F , FOLLENZI A , REATO G , SOTTILE A , NALDINI L , COMOGLIO PM (2005)
The MET oncogene drives a genetic programme linking cancer to haemostasis.
https://iris.unito.it/handle/2318/42618
C BOCCACCIO, P M COMOGLIO (2005)
A functional role for hemostasis in early cancer development.
https://iris.unito.it/handle/2318/38466
P M COMOGLIO, C BOCCACCIO (2004)
I recettori per i fattori di crescita.
https://iris.unito.it/handle/2318/10935
P COMOGLIO, C BOCCACCIO, L TRUSOLINO (2003)
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
https://iris.unito.it/handle/2318/37417
COMOGLIO P M , C BOCCACCIO (2002)
GROWTH FACTORS AND CELL SIGNALLING.
https://iris.unito.it/handle/2318/10901
BOCCACCIO C, ANDO', M, COMOGLIO PM (2002)
A differentiation switch for genetically modified hepatocytes.
https://iris.unito.it/handle/2318/31980
FOLLENZI A, SABATINO G, LOMBARDO A, BOCCACCIO C, NALDINI L (2002)
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors.
https://iris.unito.it/handle/2318/38440
COMOGLIO P M , C BOCCACCIO (2001)
WHEN REGULATION FAILS: HOW CANCER ARISES.
https://iris.unito.it/handle/2318/10902
RASOLA A, GRAMAGLIA D, C BOCCACCIO, COMOGLIO PM (2001)
Apoptosis enhancement by the HIV-1 Nef protein.
https://iris.unito.it/handle/2318/36558
PM COMOGLIO, C BOCCACCIO (2001)
Scatter factors and invasive growth.
https://iris.unito.it/handle/2318/43173
F GALIMI, E COTTONE, E VIGNA, N ARENA, C BOCCACCIO, S GIORDANO, L NALDINI, P COMOGLIO (2001)
Hepatocyte growth factor is a regulator of monocyte-macrophage function.
https://iris.unito.it/handle/2318/38181
L TRUSOLINO, S CAVASSA, P ANGELINI, M ANDO', , A BERTOTTI, P COMOGLIO, C BOCCACCIO (2000)
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.
https://iris.unito.it/handle/2318/40794
COMOGLIO P M , C BOCCACCIO (1999)
I RECETTORI PER I FATTORI DI CRESCITA.
https://iris.unito.it/handle/2318/10904
COMOGLIO PM, TAMAGNONE L, BOCCACCIO C (1999)
Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth.
https://iris.unito.it/handle/2318/40070
COMOGLIO P M , C BOCCACCIO (1998)
QUANDO FALLISCE LA REGOLAZIONE: L'INSORGENZA DEL CANCRO.
https://iris.unito.it/handle/2318/10903
BOCCACCIO C, ANDÒ M, TAMAGNONE L, BARDELLI A, MICHIELI P, BATTISTINI C, COMOGLIO PM (1998)
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.
https://iris.unito.it/handle/2318/40234
COMOGLIO P M , C BOCCACCIO (1997)
I FATTORI DI CRESCITA CONTROLLANO LA PROLIFERAZIONE CELLULARE.
https://iris.unito.it/handle/2318/10905
COMOGLIO P M , C BOCCACCIO (1996)
I RECETTORI PER I FATTORI DI CRESCITA.
https://iris.unito.it/handle/2318/10906
GRAZIANI A, GALIMI F, MEDICO E, COTTONE E, GRAMAGLIA D, BOCCACCIO C, COMOGLIO PM (1996)
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.
https://iris.unito.it/handle/2318/42709
GAMBAROTTA G, BOCCACCIO C, GIORDANO S, ANDŎ M, STELLA MC, COMOGLIO PM (1996)
Ets up-regulates MET transcription.
https://iris.unito.it/handle/2318/42931
P M COMOGLIO, C BOCCACCIO (1996)
The HGF receptor family: unconventional signal transducers for invasive cell growth.
https://iris.unito.it/handle/2318/39053
C BOCCACCIO, G GAUDINO, G GAMBAROTTA, F GALIMI, P M COMOGLIO (1994)
Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF.
https://iris.unito.it/handle/2318/36473
C BOCCACCIO, G GAUDINO, M CILLI, A MONDINO AND P M COMOGLIO (1991)
Ligand-independent tyrosine phosphorylation of the receptor encoded by the c-neu oncogene.
https://iris.unito.it/handle/2318/38439
Insegnamenti
- Cancer stem cells as therapeutical targets. Responsabile prof Carla Boccaccio
Programma MD-PhD della Scuola di Medicina - Istologia ed embriologia (canale A) (SME0716)
Laurea Magistrale in Medicina e Chirurgia - sede di Torino - TIROCINIO di CELLULE STAMINALI TUMORALI E MODELLI PRECLINICI (SME0921)
Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
Temi di ricerca
Per maggiori dettagli è possibile consultare la pagina del Docente sul sito del Dottorato in Medicina Molecolare
Attività in agenda
Organi
Ricevimento studenti
Previo appuntamento via e-mail.