Laurea Magistrale in Medicina e Chirurgia - sede di Torino

Prodotti della ricerca selezionati

De Bacco F, Orzan F, Casanova E, Prelli M, Boccaccio C. (2023) Protocol for in vitro establishment of heterogeneous stem-like cultures derived from whole human glioblastoma tumors. STAR protocols 4(4) 102705 [DOI  PMID]

De Bacco F, Orzan F, Crisafulli G, Prelli M, Isella C, Casanova E, Albano R, Reato G, Erriquez J, D'Ambrosio A, Panero M, Dall'Aglio C, Casorzo L, Cominelli M, Pagani F, Melcarne A, Zeppa P, Altieri R, Morra I, Cassoni P, Garbossa D, Cassisa A, Bartolini A, Pellegatta S, Comoglio PM, Finocchiaro G, Poliani PL, Boccaccio C. (2023) Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas. Cell reports 42(8) 112816 [DOI  PMID]

Candiello E, Reato G, Verginelli F, Gambardella G, D Ambrosio A, Calandra N, Orzan F, Iuliano A, Albano R, Sassi F, Luraghi P, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C. (2023) MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis. Molecular oncology 17(7) 1280-1301 [DOI  PMID]

Brundu S, Napolitano V, Franzolin G, Lo Cascio E, Mastrantonio R, Sardo G, Cascardi E, Verginelli F, Sarnataro S, Gambardella G, Pisacane A, Arcovito A, Boccaccio C, Comoglio PM, Giraudo E, Tamagnone L. (2023) Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary. EMBO molecular medicine 15(3) e16104 [DOI  PMID]

Altintas DM, Cerqua M, De Laurentiis A, Trusolino L, Boccaccio C, Comoglio PM. (2023) An mTOR feedback loop mediates the 'flare' ('rebound') response to MET tyrosine kinase inhibition. Scientific reports 13(1) 1378 [DOI  PMID]

Orzan F, De Bacco F, Lazzarini E, Crisafulli G, Gasparini A, Dipasquale A, Barault L, Macagno M, Persico P, Pessina F, Bono B, Giordano L, Zeppa P, Melcarne A, Cassoni P, Garbossa D, Santoro A, Comoglio PM, Indraccolo S, Simonelli M, Boccaccio C. (2023) Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation. Clinical cancer research 29(7) 1252-1266 [DOI  PMID]

Pisacane A, Cascardi E, Berrino E, Polidori A, Sarotto I, Casorzo L, Panero M, Boccaccio C, Verginelli F, Benvenuti S, Dellino M, Comoglio P, Montemurro F, Geuna E, Marchio C, Sapino A. (2023) Real-world histopathological approach to malignancy of undefined primary origin (MUO) to diagnose cancers of unknown primary (CUPs). Virchows Archiv  482(3) 463-475 [DOI  PMID]

Altintas DM, Gallo S, Basilico C, Cerqua M, Bocedi A, Vitacolonna A, Botti O, Casanova E, Rancati I, Milanese C, Notari S, Gambardella G, Ricci G, Mastroberardino PG, Boccaccio C, Crepaldi T, Comoglio PM. (2022) The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor. International journal of molecular sciences 23(20) [DOI  PMID]

Cerqua M, Botti O, Arigoni M, Gioelli N, Serini G, Calogero R, Boccaccio C, Comoglio PM, Altintas DM. (2022) MET∆14 promotes a ligand-dependent, AKT-driven invasive growth. Life science alliance 5(10) [DOI  PMID]

De Bacco F, Boccaccio C. (2021) ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference. Molecular & cellular oncology 8(5) 1990677 [DOI  PMID]

De Bacco F, Orzan F, Erriquez J, Casanova E, Barault L, Albano R, D'Ambrosio A, Bigatto V, Reato G, Patane M, Pollo B, Kuesters G, Dell'Aglio C, Casorzo L, Pellegatta S, Finocchiaro G, Comoglio PM, Boccaccio C. (2021) ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma. Cell reports 36(4) 109455 [DOI  PMID]

Verginelli F, Pisacane A, Gambardella G, D'Ambrosio A, Candiello E, Ferrio M, Panero M, Casorzo L, Benvenuti S, Cascardi E, Senetta R, Geuna E, Ballabio A, Montemurro F, Sapino A, Comoglio PM, Boccaccio C. (2021) Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition. Nature communications 12(1) 2498 [DOI  PMID]

Lupo B, Sassi F, Pinnelli M, Galimi F, Zanella ER, Vurchio V, Migliardi G, Gagliardi PA, Puliafito A, Manganaro D, Luraghi P, Kragh M, Pedersen MW, Horak ID, Boccaccio C, Medico E, Primo L, Nichol D, Spiteri I, Heide T, Vatsiou A, Graham TA, Elez E, Argiles G, Nuciforo P, Sottoriva A, Dienstmann R, Pasini D, Grassi E, Isella C, Bertotti A, Trusolino L. (2020) Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype. Science translational medicine 12(555) [DOI  PMID]

Gallo S, Spilinga M, Casanova E, Bonzano A, Boccaccio C, Comoglio PM, Crepaldi T. (2020) The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3. International journal of molecular sciences 21(15) [DOI  PMID]

Benvenuti S, Milan M, Geuna E, Pisacane A, Senetta R, Gambardella G, Stella GM, Montemurro F, Sapino A, Boccaccio C, Comoglio PM. (2020) Cancer of Unknown Primary (CUP): genetic evidence for a novel nosological entity? A case report. EMBO molecular medicine 12(7) e11756 [DOI  PMID]

Orzan F, Pagani F, Cominelli M, Triggiani L, Calza S, De Bacco F, Medicina D, Balzarini P, Panciani PP, Liserre R, Buglione M, Fontanella MM, Medico E, Galli R, Isella C, Boccaccio C, Poliani PL. (2020) A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes. Laboratory investigation 100(10) 1330-1344 [DOI  PMID]

Gallo S, Spilinga M, Albano R, Ferrauto G, Di Gregorio E, Casanova E, Balmativola D, Bonzano A, Boccaccio C, Sapino A, Comoglio PM, Crepaldi T. (2020) Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. British journal of pharmacology 177(13) 3107-3122 [DOI  PMID]

Kolling S, Ventre F, Geuna E, Milan M, Pisacane A, Boccaccio C, Sapino A, Montemurro F. (2019) "Metastatic Cancer of Unknown Primary" or "Primary Metastatic Cancer"? Frontiers in oncology 9 1546 [DOI  PMID]

Simonelli M, Dipasquale A, Orzan F, Lorenzi E, Persico P, Navarria P, Pessina F, Nibali MC, Bello L, Santoro A, Boccaccio C. (2020) Cerebrospinal fluid tumor DNA for liquid biopsy in glioma patients' management: Close to the clinic? Critical reviews in oncology/hematology 146 102879 [DOI  PMID]

Comoglio PM, Trusolino L, Boccaccio C. (2018) Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy. Nature reviews. Cancer 18(6) 341-358 [DOI  PMID]

Luraghi P, Bigatto V, Cipriano E, Reato G, Orzan F, Sassi F, De Bacco F, Isella C, Bellomo SE, Medico E, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C. (2018) A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy. Clinical cancer research 24(4) 807-820 [DOI  PMID]

Orzan F, De Bacco F, Crisafulli G, Pellegatta S, Mussolin B, Siravegna G, D'Ambrosio A, Comoglio PM, Finocchiaro G, Boccaccio C. (2017) Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor. Stem cells 35(11) 2218-2228 [DOI  PMID]

Isella C, Brundu F, Bellomo SE, Galimi F, Zanella E, Porporato R, Petti C, Fiori A, Orzan F, Senetta R, Boccaccio C, Ficarra E, Marchionni L, Trusolino L, Medico E, Bertotti A. (2017) Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer. Nature communications 8 15107 [DOI  PMID]

De Bacco F, D'Ambrosio A, Casanova E, Orzan F, Neggia R, Albano R, Verginelli F, Cominelli M, Poliani PL, Luraghi P, Reato G, Pellegatta S, Finocchiaro G, Perera T, Garibaldi E, Gabriele P, Comoglio PM, Boccaccio C. (2016) MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. EMBO molecular medicine 8(5) 550-68 [DOI  PMID]

Bigatto V, De Bacco F, Casanova E, Reato G, Lanzetti L, Isella C, Sarotto I, Comoglio PM, Boccaccio C. (2015) TNF-alpha promotes invasive growth through the MET signaling pathway. Molecular oncology 9(2) 377-88 [DOI  PMID]

Boccaccio C, Comoglio PM. (2014) MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure. Current opinion in cell biology 31 98-105 [DOI  PMID]

Boccaccio C, Luraghi P, Comoglio PM. (2014) MET-mediated resistance to EGFR inhibitors: an old liaison rooted in colorectal cancer stem cells. Cancer research 74(14) 3647-51 [DOI  PMID]

Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, Bigatto V, De Bacco F, Menietti E, Han M, Rideout WM 3rd, Perera T, Bertotti A, Trusolino L, Comoglio PM, Boccaccio C. (2014) MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer research 74(6) 1857-69 [DOI  PMID]

Boccaccio C, Comoglio PM. (2013) The MET oncogene in glioblastoma stem cells: implications as a diagnostic marker and a therapeutic target. Cancer research 73(11) 3193-9 [DOI  PMID]

Luraghi P, Schelter F, Kruger A, Boccaccio C. (2012) The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth. Frontiers in pharmacology 3 164 [DOI  PMID]

De Bacco F, Casanova E, Medico E, Pellegatta S, Orzan F, Albano R, Luraghi P, Reato G, D'Ambrosio A, Porrati P, Patane M, Maderna E, Pollo B, Comoglio PM, Finocchiaro G, Boccaccio C. (2012) The MET oncogene is a functional marker of a glioblastoma stem cell subtype. Cancer research 72(17) 4537-50 [DOI  PMID]

Gastaldi S, Sassi F, Accornero P, Torti D, Galimi F, Migliardi G, Molyneux G, Perera T, Comoglio PM, Boccaccio C, Smalley MJ, Bertotti A, Trusolino L. (2013) Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer. Oncogene 32(11) 1428-40 [DOI  PMID]

Hwang CI, Matoso A, Corney DC, Flesken-Nikitin A, Korner S, Wang W, Boccaccio C, Thorgeirsson SS, Comoglio PM, Hermeking H, Nikitin AY. (2011) Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proceedings of the National Academy of Sciences of the United States of America 108(34) 14240-5 [DOI  PMID]

Schelter F, Grandl M, Seubert B, Schaten S, Hauser S, Gerg M, Boccaccio C, Comoglio P, Kruger A. (2011) Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10. Clinical & experimental metastasis 28(8) 793-802 [DOI  PMID]

De Bacco F, Luraghi P, Medico E, Reato G, Girolami F, Perera T, Gabriele P, Comoglio PM, Boccaccio C. (2011) Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. Journal of the National Cancer Institute 103(8) 645-61 [DOI  PMID]

Schelter F, Kobuch J, Moss ML, Becherer JD, Comoglio PM, Boccaccio C, Kruger A. (2010) A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor. The Journal of biological chemistry 285(34) 26335-40 [DOI  PMID]

Boccaccio C. (2011) Hepatocyte Growth Factor: a marker and a player in disseminated intravascular coagulation. Thrombosis research 127(2) 67-9 [DOI  PMID]

Boccaccio C, Comoglio PM. (2009) Genetic link between cancer and thrombosis. Journal of clinical oncology 27(29) 4827-33 [DOI  PMID]

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE. (2009) Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28(11) 1421-31 [DOI  PMID]

Kankuri E, Babusikova O, Hlubinova K, Salmenpera P, Boccaccio C, Lubitz W, Harjula A, Bizik J. (2008) Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells. International journal of cancer 122(6) 1243-52 [DOI  PMID]

Comoglio P, Trusolino L, Boccaccio C. (2007) Scatter factor-dependent branching morphogenesis: structural and histological features. European journal of histochemistry  51 Suppl 1 79-92 [PMID]

Boccaccio C, Comoglio PM. (2006) Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nature reviews. Cancer 6(8) 637-45 [DOI  PMID]

Boccaccio C, Medico E. (2006) Cancer and blood coagulation. Cellular and molecular life sciences 63(9) 1024-7 [DOI  PMID]

Boccaccio C, Comoglio PM. (2005) A functional role for hemostasis in early cancer development. Cancer research 65(19) 8579-82 [DOI  PMID]

Boccaccio C, Sabatino G, Medico E, Girolami F, Follenzi A, Reato G, Sottile A, Naldini L, Comoglio PM. (2005) The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature 434(7031) 396-400 [DOI  PMID]

Comoglio PM, Boccaccio C, Trusolino L. (2003) Interactions between growth factor receptors and adhesion molecules: breaking the rules. Current opinion in cell biology 15(5) 565-71 [DOI  PMID]

Follenzi A, Sabatino G, Lombardo A, Boccaccio C, Naldini L. (2002) Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Human gene therapy 13(2) 243-60 [DOI  PMID]

Boccaccio C, Ando' M, Comoglio PM. (2002) A differentiation switch for genetically modified hepatocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(1) 120-2 [DOI  PMID]

Comoglio PM, Boccaccio C. (2001) Scatter factors and invasive growth. Seminars in cancer biology 11(2) 153-65 [DOI  PMID]

Galimi F, Cottone E, Vigna E, Arena N, Boccaccio C, Giordano S, Naldini L, Comoglio PM. (2001) Hepatocyte growth factor is a regulator of monocyte-macrophage function. Journal of immunology  166(2) 1241-7 [DOI  PMID]

Rasola A, Gramaglia D, Boccaccio C, Comoglio PM. (2001) Apoptosis enhancement by the HIV-1 Nef protein. Journal of immunology  166(1) 81-8 [DOI  PMID]

Trusolino L, Cavassa S, Angelini P, Ando M, Bertotti A, Comoglio PM, Boccaccio C. (2000) HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity. FASEB journal  14(11) 1629-40 [DOI  PMID]

Comoglio PM, Tamagnone L, Boccaccio C. (1999) Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth. Experimental cell research 253(1) 88-99 [DOI  PMID]

Boccaccio C, Ando M, Tamagnone L, Bardelli A, Michieli P, Battistini C, Comoglio PM. (1998) Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391(6664) 285-8 [DOI  PMID]

Gambarotta G, Boccaccio C, Giordano S, Ando M, Stella MC, Comoglio PM. (1996) Ets up-regulates MET transcription. Oncogene 13(9) 1911-7 [PMID]

Comoglio PM, Boccaccio C. (1996) The HGF receptor family: unconventional signal transducers for invasive cell growth. Genes to cells 1(4) 347-54 [DOI  PMID]

Graziani A, Galimi F, Medico E, Cottone E, Gramaglia D, Boccaccio C, Comoglio PM. (1996) The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. The Journal of biological chemistry 271(12) 6590-3 [DOI  PMID]

Boccaccio C, Gaudino G, Gambarotta G, Galimi F, Comoglio PM. (1994) Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. The Journal of biological chemistry 269(17) 12846-51 [PMID]

Boccaccio C, Gaudino G, Cilli M, Mondino A, Comoglio PM. (1991) Ligand-independent tyrosine phosphorylation of the receptor encoded by the c-neu oncogene. Growth factors 5(3) 233-42 [DOI  PMID]

Insegnamenti

• Cancer stem cells as therapeutical targets. Responsabile prof Carla Boccaccio
  Programma MD-PhD della Scuola di Medicina
• Cancer stem cells as therapeutic targets
  Molecular Medicine PhD Program
• Istologia ed embriologia (canale A) (SME0716)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• TIROCINIO di CELLULE STAMINALI TUMORALI (SME0921)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9

Temi di ricerca

Per maggiori dettagli è possibile consultare la pagina del Docente sul sito del Dottorato in Medicina Molecolare

Organi

• Department Council - Department of Oncology

• Commissione per la Didattica - Dipartimento di Oncologia
• Consiglio di Dipartimento - Dipartimento di Oncologia

• Collegio Docenti

Ricevimento studenti